| DNA detection by
release of surfactant-solubilized dyes |
Work
in the Schneider group has demonstrated
that micelle-forming DNA-binding surfactants transfer
from the micelle to free solution following binding
of a complementary DNA oligonucleotide. This project
will leverage the de-micellization process to perform
sensitive DNA detections. The fluorescent dye Nile
Red has a high quantum yield when solubilized in
the core of micelles, but a low yield in free solution.
This project will study the use of solubilized
fluorescent dyes to detect tiny amounts of DNA
in solution by de-micellization strategies. |
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